How Good Is Cannabis for Multiple Sclerosis (MS)?
Over 2.3 million people around the world live with multiple sclerosis (MS). Here’s whether cannabis can help.
Canada is one of the countries with the highest numbers of MS patients. According to MS Society of Canada, 1 in every 385 Canadians lives with this condition.
As it’s one of the most debilitating conditions, living with multiple sclerosis is a real battle.
For patients who don’t respond well to conventional MS methods, cannabis treatment seems like a very reasonable choice.
What is multiple sclerosis?
Multiple Sclerosis (otherwise known as MS) is an unpredictable, progressive neurological autoimmune disease that gradually damages the nerves of the spinal cord and brain, along with the entire immune system.
Scientists and medical experts have been trying to solve the puzzle of MS for decades, and they still can’t say with certainty what is the exact cause of it. However, some factors have been identified as potential causes of MS.
So, what do we know about multiple sclerosis?
MS is an autoimmune disease in which the immune system attacks myelin—a fatty substance that envelops nerve cells and fibers, allowing information exchange.
When there isn’t enough myelin, the brain finds it difficult to communicate with the rest of the body.
This myelin deficiency disease gradually deteriorates the nerve cells, and eventually damages them permanently.
What causes multiple sclerosis?
Although they still can’t say for sure, scientists think that certain genetic and environmental factors play a role in developing MS.
Let’s start with genetics. If your parents (or your siblings) have this disease, there’s a slightly higher chance (5%) that you’ll be diagnosed too.
Researchers also assume that people with MS are born with a genetic predisposition to react to some (still unidentified) environmental agents, which trigger this negative autoimmune response.
When it comes to the environmental factors, it’s been noticed that people from countries that are far from the equator tend to be diagnosed with MS much more than people from countries that are closer to it.
The logical scientific explanation for this is a deficiency in vitamin D. (1)
People who live near the equator are exposed to more sunny days and because of this they synthesize more vitamin D.
Since there isn’t much sunlight in places away from the equator, people need to ingest this vitamin through food, which is difficult to accomplish.
Also, some scientists presume that certain viral and bacterial infections can also cause or trigger MS, particularly because some viruses are known to cause inflammation and demyelination (breakdown of the myelin coating).
These are all theories. The truth is is that they still haven’t been confirmed.
What are the symptoms of MS?
Multiple sclerosis is a disease that affects differently. The wide range of symptoms usually affects the mind, the senses and the entire body. Some of the early signs include:
- Walking, balance and coordination issues
- Muscle spasms, pain, fatigue and weakness
- Numbness and tingling
- Problems with vision
- Cognitive issues
- Bladder issues
Since so little is known about the exact cause of this condition, and a cure hasn’t been found yet, treatment options are limited but they do exist.
These therapies usually include corticosteroids or plasma exchange, but they only slow down the progression of MS. However, not all patients respond to these treatments well enough, and some don’t respond at all.
Scientific research on cannabis and MS
Multiple sclerosis qualifies one for getting access to medical cannabis in some states in the US. In Canada, patients suffering from MS are eligible for becoming medical cannabis users.
Using cannabis to treat general symptoms of MS
In 2005, a group of researchers was looking into the effectiveness and long-term safety of tetrahydrocannabinol for MS. During a 15-week period, 630 patients with a stable form of MS were given THC or placebo.
At the end of the treatment, patients who were taking THC reported around twice as much relief from general symptoms than those who were given placebo. (2)
Using cannabis to treat muscle spasms caused by MS
Muscle spasticity and stiffness are one of the most prevalent issues MS patients have to deal with. Gaining muscle control with cannabis seems attainable for some patients.
A very comprehensive and systematic review of 34 studies (conducted over a 50-year period) from 2014 on cannabis and MS concluded that oral cannabis extracts are very effective in relieving muscle spasms, and possibly effective in treating other symptoms as well. (3)
Using cannabis to treat bladder issues caused by MS
In a 2010 study, MS patients were given Sativex (whole-plant formulation with 1:1 THC to CBD ratio), and placebo for 10 weeks.
Sativex had an impact on overactive bladder in patients with MS, providing evidence of improvement in symptoms associated with bladder dysfunction. (4)
Using cannabis to treat pain caused by MS
Here’s one interesting research about smoking cannabis and its effects on pain caused by MS.
30 MS patients were randomly given either a joint or an identical cigarette once a day for the
three days. After an eleven-day break, participants switched groups.
They reported that the treatment with cannabis significantly lessened pain, and was superior to placebo in symptom reduction. Naturally, the authors of this trial study point out that more research is needed. (5)
These findings show us that cannabis can’t cure MS, but it can at least provide a relief from the exhausting and persistent symptoms.
People living with MS frequently battle several accompanying conditions.
Best cannabis strains for multiple sclerosis
If you would like to give cannabis a try to diminish the symptoms of MS, here are just a few to help you kick off your journey.
If you’re having trouble finding these strains, ask you local budtender for help (strains are often sold under different names), and if they don’t have it, ask for a recommendation for a similar strain.
If you live in Canada, you can use Strainblazer to find strains currently sold by ACMPR licensed producers.
A very popular sativa-dominant strain for both medical and recreational users, Sour Diesel is famous for its ability to crush pain and fatigue. It’s great for relaxing both the brain and the body, but also provides enough energy to get going through the day.
One of the best-known indica strains, Critical Mass is recommended for night-time use. The reason is simple: It makes users sleepy and sluggish. According to people who use it medically, this strain works miracles when it comes to pain.
Nebula II CBD
This sativa-dominant strain with a 1:1 THC to CBD ratio is perfect for managing MS symptoms. Nebula is a good choice for daytime use: It brings forth the focus and energy. Also, it abolishes pain, depression and fatigue.
AK-47 is known for being a potent hybrid strain, mostly recommended for experienced users but very effective in killing pain and muscle spasms.
A favorite among medical consumers, Strawberry Cough boost energy levels and confidence, while relieving patients from all sorts of symptoms, including pain, spasms and fatigue.
- Ascherio A, Munger KL; Environmental risk factors for multiple sclerosis, Part II: Noninfectious factors; June 2007; Annals of Neurology; 61 (6): 504–513
- Zajicek JP, Sanders HP, Wright DE, Vickery PJ, Ingram WM, Reilly SM, Nunn AJ, Teare LJ, Fox PJ, Thompson AJ; Cannabinoids in multiple sclerosis (CAMS) study: safety and efficacy data for 12 months follow up; Journal of Neurology, Neurosurgery and Psychiatry; December 2005; 76(12):1664-1669
- Koppel BS, Brust JC, Fife T, Bronstein J, Youssof S, Gronseth G, Gloss D; Systematic review: efficacy and safety of medical marijuana in selected neurologic disorders: report of the Guideline Development Subcommittee of the American Academy of Neurology; Neurology; April 2014; 82(17):1556-1563
- Kavia RB, De Ridder D, Constantinescu CS, Stott CG, Fowler CJ; Randomized controlled trial of Sativex to treat detrusor overactivity in multiple sclerosis; Multiple Sclerosis; November 2010; 16(11):1349-1359
- Corey-Bloom J, Wolfson T, Gamst A, Jin S, Marcotte TD, Bentley H, Gouaux B; Smoked cannabis for spasticity in multiple sclerosis: a randomized, placebo-controlled trial; Canadian Medical Association Journal; July 2012; 184(10):1143-1150